Spectrophotometric Estimation of Fluvoxamine Maleate in Tablets Using Hydrotropic Agent
نویسندگان
چکیده
Several techniques are used to increase the aqueous solubilities of poorly water soluble drugs. Hydrotropic solubilization technique is one of them. In the present investigation hydrotropic solution of Urea (10M) has been used as a solubilizing agent to solubilize poorly water soluble drug. Fluvoxamine maleate shows maximum absorbance at 271 nm. Beer’s law was obeyed in the concentration range of 5-25 μg /ml. Results of analysis were validated statistically and by recovery studies. The proposed method is now simple, new, environmentally friendly, accurate and cost-effictive and successfully employed in routine analysis of fluvoxamine maleate tablets. Hydrotropic agent urea did not interfere in spectrophotometric determination.
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